{"id":18,"date":"2018-11-02T17:42:04","date_gmt":"2018-11-02T17:42:04","guid":{"rendered":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/?page_id=18"},"modified":"2022-05-26T13:37:26","modified_gmt":"2022-05-26T13:37:26","slug":"genetic-engineering","status":"publish","type":"page","link":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/genetic-engineering\/","title":{"rendered":"Genetic Engineering"},"content":{"rendered":"

Genetic Engineering by the Mule Team is funded by the following mechanisms.<\/p>\n

    \n
  1. Internal Funding from the University of Missouri<\/li>\n
  2. The National Swine Resource and Research Center<\/a><\/li>\n
  3. Subcontracts to the National Swine Resource and Research Center<\/li>\n
  4. Subcontracts or Direct Funding to one of the Principal Investigators at Missouri<\/li>\n<\/ol>\n

    Here is a partial list of the genetic modifications that have been made at the University of Missouri.<\/p>\n

      \n
    • Cancer<\/b><\/u> (CAG-Floxed-Stop, KRASG12D, p53R167H; caCSN2-miBRCA1-RASSF1; APC-\/-)<\/em><\/li>\n
    • Cardiovascular Disease <\/b>(<\/em><\/u>hFAT-1+; TEK-NOS3+; TEK-CAT+)<\/em><\/li>\n
    • Airway Disease<\/b><\/u>\u00a0<\/b><\/u>(CFTR-\/-; CFTR\u0394F508\/\u0394F508; CFTR\u0394F508\/\u0394F508, Tet-on CFTR+; CFTR\u0394F508\/\u0394F508, FABP2-CFTR+; shRNA CFTR; MUC5AC-\/-, MUC5B-\/-; CLCA1-\/-; EDA1-\/-)<\/em><\/li>\n
    • Diabetes<\/b><\/u> (ssGIP-hINS+; TIE2-GRP78+)<\/em><\/li>\n
    • Disease Resistance<\/b><\/u> (SIGLEC1-\/-; CD163-\/-; CD163-\/domain 5-hCD163L1 domain 8; CD163-\/-, SIGLEC1-\/-; TMPRSS2-\/-; ANPEP-\/-; CD1D-\/-<\/em>; ANTXR1-\/-)<\/em>
      \n<\/b><\/li>\n
    • Enhancing <\/b><\/u>Meat Quality<\/b><\/u> (hFAT1+)<\/em><\/li>\n
    • Fanconi<\/b><\/u> Anemia <\/b><\/u>\u00a0(FANCA-\/-; FANCD2-\/-)<\/em><\/li>\n
    • Heart Development<\/b><\/u> (Floxed FGF8<\/i>\/MESP1<\/i>–CRE; SAP130-\/-<\/i>)<\/li>\n
    • Maternal Recognition of Pregnancy\/Embryo Development <\/u><\/strong>(CYP19A1&2-\/-; IFNG -\/-; PTGS2-\/-; IL1B2-\/-; GLS-\/-)<\/em><\/li>\n
    • Muscular Dystrophy\/Atrophy<\/b><\/u> (DMD<\/i>+\/\u0394exon 46; COL6A3; SMN<\/i>+\/-; SMN<\/i>+\/-, hSMN2<\/i>+)<\/li>\n
    • Pharmaceuticals<\/b><\/u> (FIX<\/i>+, VWF<\/i>+, SERPINA1<\/i>+; FVIII<\/i>+, SERPINA1<\/i>+, FURIN<\/i>+)<\/li>\n
    • Phenylketonuria<\/b><\/u> (PAH<\/i>-\/-)<\/li>\n
    • Prader<\/b><\/u>-Willi Syndrome<\/b><\/u> (Imprinting region deletion)<\/em><\/li>\n
    • Regenerative <\/b><\/u>Medicine<\/b><\/u> (IL2RG+\/-; RAG2-\/-)<\/em><\/li>\n
    • Retinitis <\/b><\/u>Pigmentosa<\/b><\/u> (P23H RHO+; RHO-\/-)<\/em><\/li>\n
    • Suicide <\/b><\/u>Prodrug for Liver Transplantation<\/b><\/u> (ALB-TK1+; AFP-CDA+) <\/em><\/li>\n
    • Tracking\/Tools<\/b><\/u> (CAG-eGFP+; CMV-eGFP+; ZP3-CRE; UBC-Tomato+; CAG-Tomato+; UBC-nls eGFP+; PSMA1-eGFP fusion protein+)<\/em><\/li>\n
    • Usher Syndrome <\/b><\/u>(USH2A-\/-)<\/em><\/li>\n
    • Xenotransplantation<\/b><\/u> (GGTA1-\/-; GGTA1-\/-, CD55+; GGTA1CD55\/+; GGTA1-\/-, CD55+, CD59+, ENTPD1+, THBD+; CMAH-\/- ; FAH-\/-, RAG2-\/-; SIGLEC1-\/-, B4GALNT2-\/-; B4GALNT2L-\/-)<\/em><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      Genetic Engineering by the Mule Team is funded by the following mechanisms. Internal Funding from the University of Missouri The National Swine Resource and Research Center Subcontracts to the National Swine Resource and Research Center Subcontracts or Direct Funding to one of the Principal Investigators at Missouri Here is a partial list of the genetic […]<\/p>\n","protected":false},"author":13,"featured_media":90,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":9,"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":323,"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/pages\/18\/revisions\/323"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/media\/90"}],"wp:attachment":[{"href":"https:\/\/cafnrfaculty.missouri.edu\/muleteam\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}