List of Research Areas in the Prather Lab

    • Cancer (CAG-Floxed-Stop, KRASG12D, p53R167H; caCSN2-miBRCA1-RASSF1; APC-/-)
    • Cardiovascular Disease (hFAT-1+; TEK-NOS3+; TEK-CAT+)
    • Cystic Fibrosis (CFTR-/-; CFTRΔF508/ΔF508; CFTRΔF508/ΔF508, Tet-on CFTR+; CFTRΔF508/ΔF508, FABP2-CFTR+; shRNA CFTR; MUC5AC-/-, MUC5B-/- )
    • Diabetes (ssGIP-hINS+; TIE2-GRP78+)
    • Disease Resistance (SIGLEC1-/-; CD163-/-; CD163-/domain 5-hCD163L1 domain 8; CD163-/-, SIGLEC1-/-; TMPRSS2-/-; ANPEP-/-; ANTXR1-/-, CD1D-/-)
    • Enhancing Meat Quality (hFAT1+)
    • Fanconi Anemia Complementation Group A (FANCA-/-)
    • Heart Development (Floxed FGF8/MESP1-CRE)
    • Muscular Dystrophy/Atrophy (DMD+/Δexon 46; COL6A3; SMN+/-; SMN+/-, hSMN2+)
    • Pharmaceuticals (FIX+, VWF+, SERPINA1+; FVIII+, SERPINA1+, FURIN+)
    • Phenylketonuria (PAH-/-)
    • Prader-Willi Syndrome (Imprinting region deletion)
    • Regenerative Medicine (IL2RG+/-; RAG2-/-)
    • Retinitis Pigmentosa (P23H RHO +)
    • Suicide Prodrug for Liver Transplantation (ALB-TK1+; AFP-CDA+)
    • Tracking/Tools (CAG-eGFP+; CMV-eGFP+; ZP3-CRE; UBC-Tomato+; CAG-Tomato+; UBC-nls eGFP+; PSMA1-eGFP fusion protein +)
    • Xenotransplantation (GGTA1-/-; GGTA1-/-, CD55+; GGTA1CD55/+; GGTA1-/- , CD55+, CD59+, ENTPD1+, THBD+; CMAH-/- ; FAH-/-, RAG2-/-; SIGLEC1-/-)

Patents Resulting from Research in the Prather Lab

  1. R.S. Prather, F. Barnes, J. Robl, N.L. First & V.F. Simmon, “Multiplying Bovine Embryos”; U.S. Patent #4,994,384. Issued February 19, 1991.
  2. J. Li, A. Rieke, B. Day & R.S. Prather, “Method of Effecting Embryo Transplant”; U.S. Patent #5,558,636. Issued September 24, 1996.
  3. J. Li, A. Rieke, B. Day & R.S. Prather, “A System for Effecting Embryo Transplant”; U.S. Patent #5,656,010. Issued August 12, 1997.
  4. J. Li, A. Rieke, B. Day & R.S. Prather, “A System for Introducing a Fluid into the Uterus of an Animal”; U.S. Patent #5,916,144. Issued June 29, 1999.
  5. J. Li, A. Rieke, B. Day & R.S. Prather, “A System for Introducing a Fluid into the Uterus of an Animal”; Australia Patent #713,345. Issued March 16, 2000.
  6. J. Li, A. Rieke, B. Day & R.S. Prather, “A method for Introducing a Fluid into the Uterus of an Animal”; Australia Patent #717,684. Issued July 13, 2000.
  7. Z. Machaty & R.S. Prather, “Complete Activation of Mammalian Oocytes”; U.S. Patent #6,211,429. Issued April 3, 2001.
  8. J. Li, A. Rieke, B. Day & R.S. Prather, “A System for Introducing a Fluid into the Uterus of an Animal”; Canada Patent #2,220,550. Issued April 17, 2001.
  9. Prather, R.S., B.N. Day & R. Hawley. “Knockout swine and methods for making the same”; U.S. Patent #7,547,816. Issued June 16, 2009.
  10. Welsh, M.J., C. Rogers, R.S. Prather, J. Engelhardt, & Z. Yan. “Method of identifying compounds using a transgenic pig model of cystic fibrosis”; Provisional patent filed March 30, 2007, U.S. Patent #7,989,657. Issued August 2, 2011.
  11. Prather, R.S., R. Li, C.N. Murphy, & L. Spate. “High throughput cryopreservation of swine embryos”; U.S. Patent # 8,852,078. Issued October 7, 2014.
  12. Welsh, M.J., C.S. Rogers, R.S. Prather, J. Engelhardt, & Z. Yan. “Transgenic porcine models of cystic fibrosis”; U.S. Patent #8,618,352. Issued December 31, 2013.
  13. Welsh, M.J., C.S. Rogers, R.S. Prather, J. Engelhardt, & Z. Yan. “Transgenic pig models of cystic fibrosis”; U.S. Patent #8,912,386. Issued December 16, 2014.
  14. Welsh, M.J., C. Rogers, R.S. Prather, J. Engelhardt, & Y. Ziying. “Transgenic animal models of disease”; filed March 5, 2008. Australia. PCT/US2008/002886. WO 2008/121199 A2. Issued October 10, 2013.
  15. Prather, R.S., B.N. Day & R. Hawley. “Knockout swine and methods for making the same”; Canada #2,471,035. Issued May 13, 2014.
  16. Kim, J.H., D.N. Kwon, & R.S. Prather, K. Li. 2017. “Recombination activating gene 2 gene targeting vector, production of SCID-like miniature pigs by TALEN-mediated gene targeting and use thereof”; U.S. Patent #9,807,987. Issued November 7, 2017.
  17. Kim, J.-H., D.N. Kwon, K. Lee, & R.S. Prather. 2018. “Interleukin 2 receptor gamma gene targeting vecto, production of immune cell-deficient transgenic cloned mini pig having vector introduced therein, preparation method therefor and use thereof”; U.S. Patent #10,058,079. Issued August 28, 2018.
  18. Lee, K., & R.S. Prather. 2015. “Artificial oocyte activation”; U. S. Patent #9,783,779. Issued October 10, 2017.
  19. Prather, R.S. & K.D. Wells, K.M. Whitworth. 2017. “Porcine reproductive and respiratory syndrome virus resistant animals”; U.S. Patent 9,820,475. Issued November 21, 2017.
  20. Prather, R.S., K.D. Wells, & K.M. Whitworth. 2018. “Porcine reproductive and respiratory syndrome virus resistant animals”; Russian Patent 2644673. Issued February 13, 2018.
  21. Prather, R.S., K.D. Wells, & K.M. Whitworth. 2018. “Porcine reproductive and respiratory syndrome virus resistant animals”; Australian Patent 2017202540. Issued November 22, 2018.
  22. Welsh, M.J., C. Rogers, R.S. Prather, J. Engelhardt, & Y. Ziying. “Transgenic animal models of disease”; filed March 5, 2008. Canada. PCT/US2008/002886. WO 2008/121199 A2. Issued November 21, 2017.
  23. Kim, J.-H., D.-N. Kwon, J.Y. Park, J.H. Kim, M.-J. Kang, K. Lee, & R.S. Prather. 2018. “Cmp-acetylneuraminic acid hydroxylase targeting vector, vector-transduces transgenic animal for xenotransplantation, and method for producing same”; Japanese patent #6267785. Issued January 5, 2018.
  24. Prather, R.S., K.D. Wells, & K.M. Whitworth. 2018. “Porcine reproductive and respiratory syndrome virus resistant animals”; U.S. Patent #10,080,353. Issued September 25, 2018.
  25. Prather, R.S., K.D. Wells, & K.M. Whitworth. 2017. “Porcine reproductive and respiratory syndrome virus resistant animals”; U.S. Patent #10,405,526. Issued September 10, 2019.
  26. Prather, R.S., K.D. Wells, & K.M. Whitworth. 2018. “Pathogen-resistant animals having modified CD163 genes”; U.S. Patent #10,091,975. Issued October 9, 2018.
  27. Welsh, M.J., C. Rogers, R.S. Prather, J. Engelhardt, & Y. Ziying. 2018. “Transgenic animal models of disease”; European Patent #2141985. Issued October 17, 2018.
  28. Kim, J.-H., D.-N. Kwon, J.Y. Park, J.H. Kim, M.-J. Kang, K. Lee, & R.S. Prather. 2018. “Cmp-acetylneuraminic acid hydroxylase targeting vector, vector-transduces transgenic animal for xenotransplantation, and method for producing same”; European patent #2993234. Issued October 10, 2018.
  29. Kim, J.-H., D.N. Kwon, K. Lee, & R.S. Prather. 2019. “Interleukin 2 receptor gamma gene targeting vecto, production of immune cell-deficient transgenic cloned mini pig having vector introduced therein, preparation method therefor and use thereof”; Japanese Patent #6,464,167. Issued February 6, 2019.
  30. Prather, R.S., K.D. Wells, & K.M. Whitworth. 2019. Animales Resistentes al Virus del Sindrome Reproductivo y Respiratorio Porcino; Mexico Patent #357421. Issued July 9, 2018.
  31. Lee, K., & R.S. Prather. 2019. “Artificial oocyte activation”; U.S. Patent #10,190,093. Issued January 29, 2019.