Senior Research Specialist

Email: irqkb@missouri.edu

Education:
M.Phil. Madurai-Kamaraj University, India

Research Focus:
Researching several gene editing technologies in swine to assess different assays to evaluate how animals respond to modified gene therapies and to the delivery vectors themselves.

Publications:

1:  Kwon J, Surenkhuu B, Raju I, Atassi N, Mun J, Chen YF, Sarwar MA, Rosenblatt M, Pradeep A, An S, Dhall N, Mun C, Jain S. Pathological consequences of anti-citrullinated protein antibodies in tear fluid and therapeutic potential of pooled human immune globulin-eye drops in dry eye disease. Ocul Surf. 2020 Jan;18(1):80-97. doi: 10.1016/j.jtos.2019.10.004. Epub 2019 Oct 10. PubMed PMID: 31606460.

2: Mun C, Gulati S, Tibrewal S, Chen YF, An S, Surenkhuu B, Raju I, Buwick M, Ahn A, Kwon JE, Atassi N, Pradeep A, Rondelli D, Jain S. A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease. Transl Vis Sci Technol. 2019 May 2;8(3):10. doi: 10.1167/tvst.8.3.10. eCollection 2019 May. PubMed PMID: 31110911; PubMed Central PMCID: PMC6504128.

3: An S, Raju I, Surenkhuu B, Kwon JE, Gulati S, Karaman M, Pradeep A, Sinha S, Mun C, Jain S. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019 Jul;17(3):589-614. doi: 10.1016/j.jtos.2019.03.010. Epub 2019 Apr 6. PubMed PMID: 30965123; PubMed Central PMCID: PMC6721977.

4: Raju I, Kaushal GP, Haun RS. Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. Biol Chem. 2016 Nov 1;397(11):1135-1146.
doi: 10.1515/hsz-2015-0307. PubMed PMID: 27279059.

5: Haun RS, Quick CM, Siegel ER, Raju I, Mackintosh SG, Tackett AJ. Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers. Cancer Biol Ther.2015;16(10):1557-65. doi: 10.1080/15384047.2015.1071740. Epub 2015 Jul 15. PubMed PMID: 26176765; PubMed Central PMCID: PMC4846140.

6: Raju I, Kannan K, Abraham EC. FoxO3a Serves as a Biomarker of Oxidative Stress in Human Lens Epithelial Cells under Conditions of Hyperglycemia. PLoS One. 2013 Jun 21;8(6):e67126. doi: 10.1371/journal.pone.0067126. Print 2013. PubMed PMID: 23805295; PubMed Central PMCID: PMC3689697.

7: Raju I, Abraham EC. Mutants of human αB-crystallin cause enhanced protein aggregation and apoptosis in mammalian cells: influence of co-expression of HspB1. Biochem Biophys Res Commun. 2013 Jan 4;430(1):107-12. doi: 10.1016/j.bbrc.2012.11.051. Epub 2012 Nov 27. PubMed PMID: 23194663; PubMed Central PMCID: PMC3544980.

8: Raju I, Oonthonpan L, Abraham EC. Mutations in human αA-crystallin/sHSP affect subunit exchange interaction with αB-crystallin. PLoS One. 2012;7(2):e31421. doi: 10.1371/journal.pone.0031421. Epub 2012 Feb 8. PubMed PMID: 22347476; PubMed Central PMCID: PMC3275625.

9: Raju I, Abraham EC. Congenital cataract causing mutants of αA-crystallin/sHSP form aggregates and aggresomes degraded through ubiquitin-proteasome pathway. PLoS One. 2011;6(11):e28085. doi: 10.1371/journal.pone.0028085. Epub 2011 Nov 29. PubMed PMID: 22140512; PubMed Central PMCID: PMC3226672.

10: Raju I, Kumarasamy A, Abraham EC. Multiple aggregates and aggresomes of C-terminal truncated human αA-crystallins in mammalian cells and protection by αB-crystallin. PLoS One. 2011 May 12;6(5):e19876. doi: 10.1371/journal.pone.0019876. PubMed PMID: 21589881; PubMed Central PMCID: PMC3093407.

11: Gasser PJ, Orchinik M, Raju I, Lowry CA. Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain. J Comp Neurol. 2009 Feb 1;512(4):529-55. doi: 10.1002/cne.21921. PubMed PMID: 19025979.

12: Zou T, Ilangovan R, Yu F, Xu Z, Zhou J. SMN protects cells against mutant SOD1 toxicity by increasing chaperone activity. Biochem Biophys Res Commun. 2007 Dec 28;364(4):850-5. Epub 2007 Oct 25. PubMed PMID: 17964281; PubMed Central PMCID: PMC2169267.

13: Baker DA, Madayag A, Kristiansen LV, Meador-Woodruff JH, Haroutunian V, Raju I. Contribution of cystine-glutamate antiporters to the psychotomimetic effects
of phencyclidine. Neuropsychopharmacology. 2008 Jun;33(7):1760-72. Epub 2007 Aug 29. PubMed PMID: 17728701; PubMed Central PMCID: PMC3907109.

14: Ilangovan R, Marshall WL, Hua Y, Zhou J. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J Biol Chem. 2003 Aug 15;278(33):30993-9. Epub 2003 Jun
3. PubMed PMID: 12783893.