Lalor Foundation Postdoctoral Fellow
Education
| 2014 | Bachelor of Science Honours in Biology at Queen’s University, Kingston, ON Canada
Undergraduate Thesis Supervised by Dr. Adam Chippindale |
| 2019 | Doctorate of Philosophy in Biomedical and Molecular Sciences, specializing in Reproduction and Development at Queen’s University, Kingston, ON, Canada
Supervised by Dr. Richard Oko |
| 2020 | Postdoctoral Research Fellowship (Current) specializing in Sperm Physiology and Fertilization at University of Missouri, Columbia, MO, USA |
Employment, Experience and Academic Memberships
| 2013-2014 | Undergraduate Researcher in the Chippindale Lab at Queen’s University investigating antagonistic traits in the development of D.Melanogaster |
| 2015-2018 | Andrology Lab Assistant at Gyn-Tech Inc. performing sperm preparation and analysis for human intrauterine injections |
| 2016-2017 | Visiting Research Student in the Sutovsky Lab at the University of Missouri-Columbia, performing protein characterization in porcine spermatozoa and IVF models |
| 2016-2020 | Member of the Society for the Study of Reproduction (SSR) |
| 2016-2020 | Member of the Network of Young Researchers in Andrology (NYRA) |
| 2017-2019 | Research Collaboration with Dr. Bruce Murphy, Dr. Joao Suzuki and Dr. Luis Aguila at l’Université de Montreal performing mouse ICSI |
| 2019 | Invited Reviewer for Cellular and Molecular Life Sciences Journal |
| 2020 | Invited Speaker at the University of Queensland Sperm Morphology Standardization Program |
Awards and Professional Development
| 2015 | Graduate of the Human Placenta Workshop – Queen’s University |
| 2016-2017 | Dr. Robert John Wilson Fellowship ($10,000) |
| 2017-2018 | Ontario Graduate Scholarship ($15,000) |
| 2017-2018 | Graduate Dean Field Research Grant ($3000) |
| 2018-2019 | Ontario Graduate Scholarship- Awarded but not accepted ($15,000) |
| 2018-2019 | Dr. Robert John Wilson Fellowship ($10,000) |
| 2019 | 22nd Annual Meeting for Health Sciences Poster Winner |
| 2019
2021 |
2018-2019 Research Excellence Award for Outstanding Graduate Work in Reproduction and Developmental Sciences
Lalor Foundation Postdoctoral Fellowship |
Publications
| 2021
2021
2021
2020
|
Hamilton LE, Sutovsky P (2021) Sperm redox system equilibrium: Implications for fertilization and male fertility. In: Oxidative Stress and Toxicity in Reproductive Biology and Medicine, Kesari KK, Roychoudhury, Editors. Springer Nature Switzerland AG. Pages: In press.
Hamilton LE, Lion M, Aguila L, Suzuki J, Acteau G, Protopapas N, Wei Xu W, Sutovsky P, Baker M, Oko R (2021) Core histones are constituents of the perinuclear theca of murid spermatozoa. In. J. Mol. Sci. 22(15):8119. doi: 10.3390/ijms22158119. Hamilton, L.E., Oko, R., Sutovsky, P. (2020) Cellular and molecular events after ICSI in clinically relevant animal models. In: Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction. Palermo G and Nagy P, Editors. Cambridge University Press, In press. Kerns K, Sharif M, Zigo M, Xu W, Hamilton L, Sutovsky M, Ellersieck M, Drobnis EZ, Oko R, Miller D, Sutovsky P (2020) Sperm cohort-specific zinc signature acquisition and capacitation-induced zinc flux regulate sperm-oviduct and sperm-zona pellucida interactions. Int. J. Mol. Sci., 21(6):2121; Special Issue on Advances in Molecular Regulation of Spermatozoa Function. |
| 2019 | Hamilton, L. E., Zigo, M., Mao, J., Xu, W., Sutovsky, P., O’Flaherty, C., & Oko, R. (2019). GSTO2 Isoforms Participate in the Oxidative Regulation of the Plasmalemma in Eutherian Spermatozoa during Capacitation. Antioxidants, 8(12), 601. |
| 2019 | Hamilton, L. E., Suzuki, J., Meinsohn, M. C., Smith, O., Aguila, L., Protopapas, N., Xu, W., Sutovsky, P., & Oko, R. (2019). Sperm-borne glutathione-s-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in mice. Biology of Reproduction 101 (2), 368-376. |
| 2019 | Hamilton, L.E.*, Protopapas, N.*, Warkentin, R., Xu, W., Sutovsky, P, & Oko, R. (2019). The perforatorium and postacrosomal sheath of rat spermatozoa share common developmental origins and protein constituents. Biology of Reproduction, 100 (6), 1461-1472. |
| 2018 | Hamilton, L. E., Suzuki, J., Acteau, G., Shi, M., Xu, W., Meinsohn, M. C., Sutovsky, P & Oko, R. (2018). WBP2 shares a common location in mouse spermatozoa with WBP2NL/PAWP and like its descendent is a candidate mouse oocyte-activating factor. Biology of reproduction, 99(6), 1171-1183. |
| 2017 | Hamilton, L. E., Acteau, G., Xu, W., Sutovsky, P., & Oko, R. (2017). The developmental origin and compartmentalization of glutathione-s-transferase omega 2 isoforms in the perinuclear theca of eutherian spermatozoa. Biology of reproduction, 97(4), 612-621. |
*Represents equal contribution amongst authors