Genetic Engineering by the Mule Team is funded by the following mechanisms.
- Internal Funding from the University of Missouri
- The National Swine Resource and Research Center
- Subcontracts to the National Swine Resource and Research Center
- Subcontracts or Direct Funding to one of the Principal Investigators at Missouri
Here is a partial list of the genetic modifications that have been made at the University of Missouri.
- Cancer (CAG-Floxed-Stop, KRASG12D, p53R167H; caCSN2-miBRCA1-RASSF1; APC-/-)
- Cardiovascular Disease (hFAT-1+; TEK-NOS3+; TEK-CAT+)
- Airway Disease (CFTR-/-; CFTRΔF508/ΔF508; CFTRΔF508/ΔF508, Tet-on CFTR+; CFTRΔF508/ΔF508, FABP2-CFTR+; shRNA CFTR; MUC5AC-/-, MUC5B-/-; CLCA1-/-; EDA1-/-)
- Diabetes (ssGIP-hINS+; TIE2-GRP78+)
- Disease Resistance (SIGLEC1-/-; CD163-/-; CD163-/domain 5-hCD163L1 domain 8; CD163-/-, SIGLEC1-/-; TMPRSS2-/-; ANPEP-/-; CD1D-/-; ANTXR1-/-)
- Enhancing Meat Quality (hFAT1+)
- Fanconi Anemia (FANCA-/-; FANCD2-/-)
- Heart Development (Floxed FGF8/MESP1–CRE; SAP130-/-)
- Maternal Recognition of Pregnancy/Embryo Development (CYP19A1&2-/-; IFNG -/-; PTGS2-/-; IL1B2-/-; GLS-/-)
- Muscular Dystrophy/Atrophy (DMD+/Δexon 46; COL6A3; SMN+/-; SMN+/-, hSMN2+)
- Pharmaceuticals (FIX+, VWF+, SERPINA1+; FVIII+, SERPINA1+, FURIN+)
- Phenylketonuria (PAH-/-)
- Prader-Willi Syndrome (Imprinting region deletion)
- Regenerative Medicine (IL2RG+/-; RAG2-/-)
- Retinitis Pigmentosa (P23H RHO+; RHO-/-)
- Suicide Prodrug for Liver Transplantation (ALB-TK1+; AFP-CDA+)
- Tracking/Tools (CAG-eGFP+; CMV-eGFP+; ZP3-CRE; UBC-Tomato+; CAG-Tomato+; UBC-nls eGFP+; PSMA1-eGFP fusion protein+)
- Usher Syndrome (USH2A-/-)
- Xenotransplantation (GGTA1-/-; GGTA1-/-, CD55+; GGTA1CD55/+; GGTA1-/-, CD55+, CD59+, ENTPD1+, THBD+; CMAH-/- ; FAH-/-, RAG2-/-; SIGLEC1-/-, B4GALNT2-/-; B4GALNT2L-/-)